| English Premiership |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 13-Aug-05 | H | Blackburn Rovers | W | 3-1 | (0-1) | Sheringham 46; Reo-Coker 62; Etherington 80 | 33,305 |
| 2 | 20-Aug-05 | A | Newcastle United | D | 0-0 | (0-0) | | 51,620 |
| 3 | 27-Aug-05 | H | Bolton Wanderers | L | 1-2 | (0-0) | Sheringham 90p | 31,629 |
| 4 | 12-Sep-05 | H | Aston Villa | W | 4-0 | (2-0) | Harewood 25, 29, 50; Benayoun 89 | 29,582 |
| 5 | 17-Sep-05 | A | Fulham | W | 2-1 | (0-0) | Harewood 46; Warner(og) 52 | 21,907 |
| 6 | 24-Sep-05 | H | Arsenal | D | 0-0 | (0-0) | | 34,742 |
| 7 | 01-Oct-05 | A | Sunderland | D | 1-1 | (0-1) | Benayoun 71 | 31,212 |
| 8 | 16-Oct-05 | A | Manchester City | L | 1-2 | (0-1) | Zamora 90 | 43,647 |
| 9 | 23-Oct-05 | H | Middlesbrough | W | 2-1 | (0-0) | Sheringham 65; Riggott(og) 73 | 34,612 |
| 10 | 29-Oct-05 | A | Liverpool | L | 0-2 | (0-1) | | 44,537 |
| 11 | 05-Nov-05 | H | West Bromwich Albion | W | 1-0 | (0-0) | Sheringham 56 | 34,325 |
| 12 | 20-Nov-05 | A | Tottenham Hotspur | D | 1-1 | (0-1) | Ferdinand 90 | 36,154 |
| 13 | 27-Nov-05 | H | Manchester United | L | 1-2 | (1-0) | Harewood 1 | 34,755 |
| 14 | 05-Dec-05 | A | Birmingham City | W | 2-1 | (2-1) | Zamora 35; Harewood 45 | 24,010 |
| 15 | 10-Dec-05 | A | Blackburn Rovers | L | 2-3 | (1-0) | Zamora 45; Harewood 62 | 20,370 |
| 16 | 14-Dec-05 | A | Everton | W | 2-1 | (1-1) | Weir 18; Zamora 66 | 35,704 |
| 17 | 17-Dec-05 | H | Newcastle United | L | 2-4 | (1-2) | Solano(og) 19; Harewood 72p | 34,836 |
| 18 | 26-Dec-05 | A | Portsmouth | D | 1-1 | (0-1) | Collins 55 | 20,168 |
| 19 | 28-Dec-05 | H | Wigan Athletic | L | 0-2 | (0-2) | | 34,131 |
| 20 | 31-Dec-05 | A | Charlton Athletic | L | 0-2 | (0-1) | | 25,952 |
| 21 | 02-Jan-06 | H | Chelsea | L | 1-3 | (1-1) | Harewood 45 | 34,758 |
| 22 | 14-Jan-06 | A | Aston Villa | W | 2-1 | (0-1) | Zamora 50; Harewood 59p | 36,700 |
| 23 | 23-Jan-06 | H | Fulham | W | 2-1 | (2-0) | Ferdinand 17; Benayoun 28 | 29,812 |
| 24 | 01-Feb-06 | A | Arsenal | W | 3-2 | (2-1) | Reo-Coker 25; Zamora 32; Etherington 80 | 38,216 |
| 25 | 04-Feb-06 | H | Sunderland | W | 2-0 | (0-0) | Ashton 81; Konchesky 87 | 34,745 |
| 26 | 13-Feb-06 | H | Birmingham City | W | 3-0 | (1-0) | Harewood 11, 63; Ashton 65 | 31,294 |
| 27 | 04-Mar-06 | H | Everton | D | 2-2 | (2-1) | Harewood 10; Ashton 23 | 34,866 |
| 28 | 11-Mar-06 | A | Bolton Wanderers | L | 1-4 | (0-2) | Sheringham 79 | 24,461 |
| 29 | 18-Mar-06 | H | Portsmouth | L | 2-4 | (0-3) | Sheringham 69; Benayoun 91 | 34,837 |
| 30 | 25-Mar-06 | A | Wigan Athletic | W | 2-1 | (0-0) | Harewood 52; Reo-Coker 91 | 18,736 |
| 31 | 29-Mar-06 | A | Manchester United | L | 0-1 | (0-0) | | 69,522 |
| 32 | 02-Apr-06 | H | Charlton Athletic | D | 0-0 | (0-0) | | 34,753 |
| 33 | 09-Apr-06 | A | Chelsea | L | 1-4 | (1-2) | Collins 10 | 41,919 |
| 34 | 15-Apr-06 | H | Manchester City | W | 1-0 | (1-0) | Newton 15 | 34,305 |
| 35 | 17-Apr-06 | A | Middlesbrough | L | 0-2 | (0-1) | | 27,658 |
| 36 | 26-Apr-06 | H | Liverpool | L | 1-2 | (0-1) | Reo-Coker 46 | 34,852 |
| 37 | 01-May-06 | A | West Bromwich Albion | W | 1-0 | (1-0) | Reo-Coker 42 | 24,462 |
| 38 | 07-May-06 | H | Tottenham Hotspur | W | 2-1 | (1-1) | Fletcher 10; Benayoun 80 | 34,970 |
|
|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 07-Jan-06 | A | Norwich City | W | 2-1 | (1-0) | Mullins 5; Zamora 56 | 23,968 |
| 4 | 28-Jan-06 | H | Blackburn Rovers | W | 4-2 | (2-1) | Sheringham 33p; Etherington 37; Khizanishvili(og) 59; Zamora 73 | 23,700 |
| 5 | 18-Feb-06 | A | Bolton Wanderers | D | 0-0 | (0-0) | | 17,120 |
| 5r | 15-Mar-06 | H | Bolton Wanderers | W | 2-1 | (1-1) | Jaaskelainen(og) 10; Harewood 96 [aet] | --,--- |
| QF | 20-Mar-06 | A | Manchester City | W | 2-1 | (1-0) | Ashton 41, 69 | --,--- |
| SF | 23-Apr-06 | A | Middlesbrough | W | 1-0 | (0-0) | Harewood 78 | 39,148 |
| F | 13-May-06 | A | Liverpool | D | 3-3 | (2-1) | Carragher(og) 21; Ashton 28; Konchesky 64 [aet, pen 3-1] | 74,000 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 2 | 20-Sep-05 | A | Sheffield Wednesday | W | 4-2 | (1-0) | Zamora 2, 63; Dailly 54; Bellion 84 | 14,976 |
| 3 | 26-Oct-05 | A | Bolton Wanderers | L | 0-1 | (0-0) | | 10,927 |
|
|
Home and away results against each team, listed in the current league table standings