| English Premiership |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 14-Aug-05 | H | Newcastle United | W | 2-0 | (0-0) | Henry 81p; van Persie 87 | 38,072 |
| 2 | 21-Aug-05 | A | Chelsea | L | 0-1 | (0-0) | | 42,136 |
| 3 | 24-Aug-05 | H | Fulham | W | 4-1 | (1-1) | Cygan 42, 90; Henry 53, 82 | 37,867 |
| 4 | 10-Sep-05 | A | Middlesbrough | L | 1-2 | (0-1) | Reyes 90 | 28,075 |
| 5 | 19-Sep-05 | H | Everton | W | 2-0 | (2-0) | Campbell 11, 30 | 38,121 |
| 6 | 24-Sep-05 | A | West Ham United | D | 0-0 | (0-0) | | 34,742 |
| 7 | 02-Oct-05 | H | Birmingham City | W | 1-0 | (0-0) | Clemence(og) 80 | 37,891 |
| 8 | 15-Oct-05 | A | West Bromwich Albion | L | 1-2 | (0-1) | Senderos 63 | 26,604 |
| 9 | 22-Oct-05 | H | Manchester City | W | 1-0 | (0-0) | Pires 60p | 38,189 |
| 10 | 29-Oct-05 | A | Tottenham Hotspur | D | 1-1 | (0-1) | Pires 76 | 36,154 |
| 11 | 05-Nov-05 | H | Sunderland | W | 3-1 | (2-0) | van Persie 11; Henry 35, 81 | 38,210 |
| 12 | 19-Nov-05 | A | Wigan Athletic | W | 3-2 | (3-2) | van Persie 10; Henry 20, 40 | 25,004 |
| 13 | 26-Nov-05 | H | Blackburn Rovers | W | 3-0 | (2-0) | Fabregas 3; Henry 44; van Persie 89 | 38,192 |
| 14 | 03-Dec-05 | A | Bolton Wanderers | L | 0-2 | (0-2) | | 26,792 |
| 15 | 10-Dec-05 | A | Newcastle United | L | 0-1 | (0-0) | | 52,297 |
| 16 | 18-Dec-05 | H | Chelsea | L | 0-2 | (0-1) | | 38,347 |
| 17 | 26-Dec-05 | A | Charlton Athletic | W | 1-0 | (0-0) | Reyes 57 | 27,111 |
| 18 | 28-Dec-05 | H | Portsmouth | W | 4-0 | (4-0) | Bergkamp 6; Reyes 12; Henry 36, 42p | 38,223 |
| 19 | 31-Dec-05 | A | Aston Villa | D | 0-0 | (0-0) | | 37,114 |
| 20 | 03-Jan-06 | H | Manchester United | D | 0-0 | (0-0) | | 38,313 |
| 21 | 14-Jan-06 | H | Middlesbrough | W | 7-0 | (4-0) | Henry 17, 29, 67; Senderos 21; Pires 45; Gilberto Silva 58; Hleb 83 | 38,186 |
| 22 | 21-Jan-06 | A | Everton | L | 0-1 | (0-1) | | 36,920 |
| 23 | 01-Feb-06 | H | West Ham United | L | 2-3 | (1-2) | Henry 45; Pires 89 | 38,216 |
| 24 | 04-Feb-06 | A | Birmingham City | W | 2-0 | (1-0) | Adebayor 21; Henry 63 | 27,075 |
| 25 | 11-Feb-06 | H | Bolton Wanderers | D | 1-1 | (0-1) | Gilberto Silva 91 | 38,193 |
| 26 | 14-Feb-06 | A | Liverpool | L | 0-1 | (0-0) | | 44,065 |
| 27 | 25-Feb-06 | A | Blackburn Rovers | L | 0-1 | (0-1) | | 22,504 |
| 28 | 04-Mar-06 | A | Fulham | W | 4-0 | (2-0) | Henry 31, 77; Adebayor 35; Fabregas 86 | 22,397 |
| 29 | 12-Mar-06 | H | Liverpool | W | 2-1 | (1-0) | Henry 21, 83 | 38,221 |
| 30 | 18-Mar-06 | H | Charlton Athletic | W | 3-0 | (2-0) | Pires 13; Adebayor 32; Hleb 49 | 38,223 |
| 31 | 01-Apr-06 | H | Aston Villa | W | 5-0 | (2-0) | Adebayor 19; Henry 25, 46; van Persie 71; Diaby 80 | 38,183 |
| 32 | 09-Apr-06 | A | Manchester United | L | 0-2 | (0-0) | | 70,908 |
| 33 | 12-Apr-06 | A | Portsmouth | D | 1-1 | (1-0) | Henry 36 | 20,230 |
| 34 | 15-Apr-06 | H | West Bromwich Albion | W | 3-1 | (1-0) | Hleb 44; Pires 76; Bergkamp 89 | 38,167 |
| 35 | 22-Apr-06 | H | Tottenham Hotspur | D | 1-1 | (0-0) | Henry 84 | 38,326 |
| 36 | 01-May-06 | A | Sunderland | W | 3-0 | (3-0) | Collins(og) 29; Fabregas 40; Henry 43 | 44,003 |
| 37 | 04-May-06 | A | Manchester City | W | 3-1 | (1-1) | Ljungberg 30; Reyes 78, 84 | 41,875 |
| 38 | 07-May-06 | H | Wigan Athletic | W | 4-2 | (2-2) | Pires 8; Henry 35, 56, 76p | 38,359 |
|
|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 07-Jan-06 | H | Cardiff City | W | 2-1 | (2-0) | Pires 5, 17 | 36,552 |
| 4 | 28-Jan-06 | A | Bolton Wanderers | L | 0-1 | (0-0) | | 13,326 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 25-Oct-05 | A | Sunderland | W | 3-0 | (0-0) | Eboue 60; van Persie 66p, 86 | 47,366 |
| 4 | 29-Nov-05 | H | Reading | W | 3-0 | (2-0) | Reyes 11; van Persie 41; Lupoli 64 | 36,167 |
| QF | 21-Dec-05 | A | Doncaster Rovers | D | 2-2 | (0-1) | Owusu-Abeyie 62; Gilberto Silva 120 [aet, pen 1-3] | 10,006 |
| SF L1 | 10-Jan-06 | A | Wigan Athletic | L | 0-1 | (0-0) | | 12,181 |
| SF L2 | 24-Jan-06 | H | Wigan Athletic | W | 2-1 | (0-0) | Henry 65; van Persie 108 [aet] | --,--- |
|
|
| Community Shield |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| F | 07-Aug-05 | A | Chelsea | L | 1-2 | (0-1) | Fabregas 65 | 58,014 |
|
|
| UEFA Champions League |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 Gp B | 14-Sep-05 | H | FC Thun | W | 2-1 | (0-0) | Gilberto Silva 51; Bergkamp 90 | --,--- |
| 1 Gp B | 27-Sep-05 | A | Ajax | W | 2-1 | (1-0) | Ljungberg 1; Pires 68p | 50,000 |
| 1 Gp B | 18-Oct-05 | A | Sparta Prague | W | 2-0 | (1-0) | Henry 20, 73 | 12,528 |
| 1 Gp B | 02-Nov-05 | H | Sparta Prague | W | 3-0 | (1-0) | Henry 22; van Persie 80, 85 | 35,155 |
| 1 Gp B | 22-Nov-05 | A | FC Thun | W | 1-0 | (0-0) | Pires 87p | 32,000 |
| 1 Gp B | 07-Dec-05 | H | Ajax | D | 0-0 | (0-0) | | 35,376 |
| 16 L1 | 21-Feb-06 | A | Real Madrid | W | 1-0 | (0-0) | Henry 47 | 80,000 |
| 16 L2 | 08-Mar-06 | H | Real Madrid | D | 0-0 | (0-0) | | --,--- |
| QF | 28-Mar-06 | H | Juventus | W | 2-0 | (1-0) | Fabregas 40; Henry 69 | 35,472 |
| QF | 05-Apr-06 | A | Juventus | D | 0-0 | (0-0) | | --,--- |
| SF | 19-Apr-06 | H | Villarreal | W | 1-0 | (1-0) | Toure 41 | 35,438 |
| SF | 25-Apr-06 | A | Villarreal | D | 0-0 | (0-0) | | --,--- |
| F | 17-May-06 | A | Barcelona | L | 1-2 | (1-0) | Campbell 37 | 79,500 |
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|
Home and away results against each team, listed in the current league table standings