| English Premiership |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 14-Aug-04 | H | Newcastle United | D | 2-2 | (0-1) | Downing 73; Hasselbaink 90 | 34,268 |
| 2 | 22-Aug-04 | A | Arsenal | L | 3-5 | (1-1) | Job 43; Hasselbaink 50; Queudrue 53 | 37,415 |
| 3 | 25-Aug-04 | A | Fulham | W | 2-0 | (0-0) | Viduka 54; Nemeth 79 | 17,759 |
| 4 | 28-Aug-04 | H | Crystal Palace | W | 2-1 | (0-0) | Popovic(og) 61; Hasselbaink 78 | 31,560 |
| 5 | 11-Sep-04 | H | Birmingham City | W | 2-1 | (1-1) | Viduka 27, 48 | 30,252 |
| 6 | 19-Sep-04 | A | Everton | L | 0-1 | (0-0) | | 34,078 |
| 7 | 25-Sep-04 | H | Chelsea | L | 0-1 | (0-0) | | 32,341 |
| 8 | 03-Oct-04 | A | Manchester United | D | 1-1 | (1-0) | Downing 33 | 67,988 |
| 9 | 16-Oct-04 | A | Blackburn Rovers | W | 4-0 | (0-0) | Hasselbaink 46, 57, 90; Boateng 50 | 20,385 |
| 10 | 24-Oct-04 | H | Portsmouth | D | 1-1 | (0-1) | Downing 74 | 30,964 |
| 11 | 30-Oct-04 | A | Charlton Athletic | W | 2-1 | (1-0) | El Karkouri(og) 21; Zenden 58 | 26,031 |
| 12 | 07-Nov-04 | H | Bolton Wanderers | D | 1-1 | (0-0) | Boateng 90 | 29,656 |
| 13 | 14-Nov-04 | A | West Bromwich Albion | W | 2-1 | (1-1) | Purse(og) 32; Zenden 52 | 24,008 |
| 14 | 20-Nov-04 | H | Liverpool | W | 2-0 | (1-0) | Riggott 36; Zenden 62 | 34,751 |
| 15 | 28-Nov-04 | A | Tottenham Hotspur | L | 0-2 | (0-0) | | 35,772 |
| 16 | 06-Dec-04 | H | Manchester City | W | 3-2 | (1-1) | Viduka 9, 54; Hasselbaink 65 | 29,787 |
| 17 | 11-Dec-04 | A | Southampton | D | 2-2 | (0-1) | Higginbotham(og) 89; Downing 90 | 29,018 |
| 18 | 18-Dec-04 | H | Aston Villa | W | 3-0 | (1-0) | Hasselbaink 20; Job 68; Reiziger 88 | 31,338 |
| 19 | 26-Dec-04 | A | Birmingham City | L | 0-2 | (0-2) | | 29,082 |
| 20 | 28-Dec-04 | H | Norwich City | W | 2-0 | (0-0) | Job 52, 54 | 34,836 |
| 21 | 01-Jan-05 | H | Manchester United | L | 0-2 | (0-1) | | 34,199 |
| 22 | 04-Jan-05 | A | Chelsea | L | 0-2 | (0-2) | | 40,982 |
| 23 | 16-Jan-05 | H | Everton | D | 1-1 | (1-0) | Zenden 26 | 31,794 |
| 24 | 22-Jan-05 | A | Norwich City | D | 4-4 | (1-1) | Hasselbaink 34, 78; Queudrue 49, 55 | 24,547 |
| 25 | 01-Feb-05 | A | Portsmouth | L | 1-2 | (1-1) | Christie 35 | 19,620 |
| 26 | 05-Feb-05 | H | Blackburn Rovers | W | 1-0 | (1-0) | Queudrue 35 | 30,564 |
| 27 | 12-Feb-05 | A | Bolton Wanderers | D | 0-0 | (0-0) | | 24,322 |
| 28 | 27-Feb-05 | H | Charlton Athletic | D | 2-2 | (0-1) | Riggott 74; Graham 86 | 29,603 |
| 29 | 05-Mar-05 | A | Aston Villa | L | 0-2 | (0-0) | | 34,201 |
| 30 | 20-Mar-05 | H | Southampton | L | 1-3 | (1-1) | Hasselbaink 41 | 30,082 |
| 31 | 02-Apr-05 | A | Crystal Palace | W | 1-0 | (1-0) | Queudrue 35 | 24,274 |
| 32 | 09-Apr-05 | H | Arsenal | L | 0-1 | (0-0) | | 33,874 |
| 33 | 19-Apr-05 | H | Fulham | D | 1-1 | (0-0) | Zenden 90p | 30,650 |
| 34 | 23-Apr-05 | H | West Bromwich Albion | W | 4-0 | (3-0) | Nemeth 27, 37; Hasselbaink 33; Downing 90 | 32,951 |
| 35 | 27-Apr-05 | A | Newcastle United | D | 0-0 | (0-0) | | 52,047 |
| 36 | 30-Apr-05 | A | Liverpool | D | 1-1 | (1-0) | Nemeth 4 | 43,250 |
| 37 | 07-May-05 | H | Tottenham Hotspur | W | 1-0 | (1-0) | Boateng 11 | 34,766 |
| 38 | 15-May-05 | A | Manchester City | D | 1-1 | (1-0) | Hasselbaink 23 | 47,221 |
|
|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 08-Jan-05 | A | Notts County | W | 2-1 | (0-1) | Doriva 54; Job 76 | 13,671 |
| 4 | 29-Jan-05 | A | Manchester United | L | 0-3 | (0-1) | | 67,251 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 27-Oct-04 | H | Coventry City | W | 3-0 | (2-0) | Nemeth 4; Morrison 25; Graham 70 | 11,833 |
| 4 | 10-Nov-04 | A | Liverpool | L | 0-2 | (0-0) | | 28,176 |
|
|
| UEFA Cup Finals |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| Gp E | 21-Oct-04 | A | Egaleo Athens | W | 1-0 | (0-0) | Downing 78 | 4,000 |
| Gp E | 04-Nov-04 | H | Lazio | W | 2-0 | (1-0) | Zenden 16, 71 | 33,991 |
| Gp E | 25-Nov-04 | A | Villarreal | L | 0-2 | (0-1) | | 16,000 |
| Gp E | 15-Dec-04 | H | Partizan Belgrade | W | 3-0 | (2-0) | Nemeth 10; Job 22; Morrison 90 | 20856 |
| 2 L1 | 17-Feb-05 | A | Graz AK | D | 2-2 | (0-0) | Zenden 51; Hasselbaink 66 | 13,000 |
| 2 L2 | 24-Feb-05 | H | Graz AK | W | 2-1 | (1-1) | Morrison 19; Hasselbaink 61 | 20,371 |
| 3 L1 | 10-Mar-05 | H | Sporting Lisbon | L | 2-3 | (0-0) | Job 79; Riggott 86 | 23,739 |
| 3 L2 | 17-Mar-05 | A | Sporting Lisbon | L | 0-1 | (0-0) | | 21,217 |
|
|
| UEFA Cup Qual |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 L1 | 16-Sep-04 | H | Banik Ostrava | W | 3-0 | (0-0) | Hasselbaink 57; Viduka 63, 80 | 29,746 |
| 1 L2 | 30-Sep-04 | A | Banik Ostrava | D | 1-1 | (0-1) | Morrison 90 | 15,351 |
|
|
Home and away results against each team, listed in the current league table standings