| German Bundesliga |
| No. | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 12-Aug-00 | H | Wolfsburg | W | 2-0 | (2-0) | 25,000 |
| U Kirsten 15, 25p |
| 2 | 19-Aug-00 | A | Stuttgart | L | 1-4 | (0-2) | 25,000 |
| M Ballack 61 |
| 3 | 05-Sep-00 | H | Unterhaching | W | 1-0 | (1-0) | 22,500 |
| M Ballack 24 |
| 4 | 09-Sep-00 | A | Cologne | D | 1-1 | (1-0) | 40,000 |
| U Kirsten 32 |
| 5 | 16-Sep-00 | H | Hansa Rostock | L | 1-2 | (0-2) | 20,000 |
| P Rink 47 |
| 6 | 23-Sep-00 | A | Cottbus | W | 2-1 | (1-1) | 15,500 |
| P Rink 24; T Brdaric 89 |
| 7 | 30-Sep-00 | H | 1860 Munich | D | 0-0 | (0-0) | 22,500 |
| |
| 8 | 14-Oct-00 | A | Werder Bremen | D | 3-3 | (1-0) | 27,000 |
| O Neuville 21, 55; M Ballack 81p |
| 9 | 21-Oct-00 | H | Borussia Dortmund | W | 2-0 | (1-0) | 22,500 |
| J Nowotny 25; O Neuville 62 |
| 10 | 28-Oct-00 | A | Schalke 04 | D | 0-0 | (0-0) | 45,000 |
| |
| 11 | 03-Nov-00 | H | Eintracht Frankfurt | W | 1-0 | (0-0) | 22,500 |
| M Ballack 79 |
| 12 | 11-Nov-00 | A | Freiburg | W | 1-0 | (0-0) | 25,000 |
| C Ramelow 62 |
| 13 | 18-Nov-00 | A | Hamburg | W | 3-1 | (2-1) | 49,000 |
| P Rink 1, 33; O Neuville 73 |
| 14 | 26-Nov-00 | H | Kaiserslautern | W | 4-2 | (2-1) | 22,500 |
| O Neuville 30, 86; U Kirsten 37; M Ballack 69p |
| 15 | 02-Dec-00 | A | Bayern Munich | L | 0-2 | (0-1) | 48,000 |
| |
| 16 | 10-Dec-00 | H | Hertha Berlin | W | 4-0 | (2-0) | 22,500 |
| O Neuville 7, 19; C Ramelow 67; P Rink 82p |
| 17 | 13-Dec-00 | A | Bochum | L | 2-3 | (0-1) | 15,800 |
| U Kirsten 67; O Neuville 76 |
| 18 | 16-Dec-00 | A | Wolfsburg | L | 0-2 | (0-0) | 13,000 |
| |
| 19 | 28-Jan-01 | H | Stuttgart | W | 4-0 | (0-0) | 22,500 |
| B Schneider 46; U Kirsten 49p, 67p; M Ballack 51 |
| 20 | 04-Feb-01 | A | Unterhaching | W | 2-1 | (1-1) | 9,000 |
| U Kirsten 26; O Neuville 53 |
| 21 | 10-Feb-01 | H | Cologne | W | 4-1 | (0-1) | 22,500 |
| Lucio 57, 90; M Ballack 65; O Neuville 78 |
| 22 | 17-Feb-01 | A | Hansa Rostock | L | 1-2 | (1-1) | 12,000 |
| U Kirsten 23 |
| 23 | 23-Feb-01 | H | Cottbus | L | 1-3 | (0-2) | 22,000 |
| Ze Roberto 74 |
| 24 | 04-Mar-01 | A | 1860 Munich | L | 0-1 | (0-0) | 21,500 |
| |
| 25 | 09-Mar-01 | H | Werder Bremen | W | 3-0 | (1-0) | 22,500 |
| Lucio 12; O Neuville 54; T Brdaric 62 |
| 26 | 17-Mar-01 | A | Borussia Dortmund | W | 3-1 | (2-1) | 68,600 |
| B Schneider 7; U Kirsten 10; T Brdaric 90 |
| 27 | 31-Mar-01 | H | Schalke 04 | L | 0-3 | (0-1) | 22,500 |
| |
| 28 | 07-Apr-01 | A | Eintracht Frankfurt | W | 3-1 | (1-0) | 27,000 |
| U Kirsten 23; Lucio 67, 82 |
| 29 | 14-Apr-01 | H | Freiburg | L | 1-3 | (0-1) | 22,500 |
| Ze Roberto 50 |
| 30 | 21-Apr-01 | H | Hamburg | D | 1-1 | (1-1) | 22,500 |
| U Kirsten 45 |
| 31 | 28-Apr-01 | A | Kaiserslautern | W | 1-0 | (1-0) | 41,500 |
| O Neuville 9 |
| 32 | 05-May-01 | H | Bayern Munich | L | 0-1 | (0-0) | 22,500 |
| |
| 33 | 12-May-01 | A | Hertha Berlin | D | 1-1 | (0-1) | 50,000 |
| O Neuville 62 |
| 34 | 19-May-01 | H | Bochum | W | 1-0 | (1-0) | 22,500 |
| O Neuville 22 |
| German Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 27-Aug-00 | A | Fortuna Köln | W | 4-0 | (2-0) | 4,000 |
| T Brdaric 7; R Kovac 30; P Rink 87, 90 |
| 2 | 31-Oct-00 | A | TSV Alemannia Aachen | W | 2-1 | (1-0) | 20,300 |
| C Ramelow 13; T Brdaric 71 |
| 3 | 29-Nov-00 | A | Freiburg | L | 2-3 | (1-2) | 18,000 |
| R Ponte 23; U Kirsten 74 |
| UEFA Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 3 L1 | 23-Nov-00 | H | AEK Athens | D | 4-4 | (2-1) | 22,500 |
| U Kirsten 25, 42; R Kovac 48; C Ramelow 90 |
| 3 L2 | 07-Dec-00 | A | AEK Athens | L | 0-2 | (0-1) | 32,200 |
| |
| UEFA Champions League |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 Gp A | 12-Sep-00 | A | Spartak Moscow | L | 0-2 | (0-0) | 40,000 |
| |
| 1 Gp A | 20-Sep-00 | H | Sporting Lisbon | W | 3-2 | (0-1) | 22,500 |
| C Ramelow 65; T Brdaric 73; O Neuville 77 |
| 1 Gp A | 27-Sep-00 | H | Real Madrid | L | 2-3 | (2-1) | 22,500 |
| B Schneider 27; M Ballack 42 |
| 1 Gp A | 17-Oct-00 | A | Real Madrid | L | 3-5 | (1-2) | 60,000 |
| T Brdaric 20; U Kirsten 55; P Rink 77 |
| 1 Gp A | 25-Oct-00 | H | Spartak Moscow | W | 1-0 | (0-0) | 20,000 |
| M Ballack 52 |
| 1 Gp A | 07-Nov-00 | A | Sporting Lisbon | D | 0-0 | (0-0) | 10,000 |
| |
Home and away results against each team, listed in the current league table standings
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.