| Spanish Primera Liga |
| No. | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 09-Sep-00 | H | Athletic Bilbao | W | 2-0 | (0-0) | 33,000 |
| Victor 53p; W Pandiani 90 |
| 2 | 16-Sep-00 | A | Racing Santander | W | 3-0 | (1-0) | 14,000 |
| J Valeron 33; Manuel Pablo 58; Fran 84 |
| 3 | 23-Sep-00 | A | Real Sociedad | D | 1-1 | (0-1) | 19,000 |
| W Pandiani 63 |
| 4 | 30-Sep-00 | H | Barcelona | W | 2-0 | (0-0) | 35,000 |
| Donato 64; D Tristan 74 |
| 5 | 14-Oct-00 | A | Real Madrid | L | 0-3 | (0-2) | 75,000 |
| |
| 6 | 21-Oct-00 | H | Real Mallorca | D | 1-1 | (0-0) | 24,000 |
| J Valeron 78 |
| 7 | 28-Oct-00 | A | Numancia | W | 2-1 | (2-0) | 8,500 |
| Donato 14; Fernando 29 |
| 8 | 31-Oct-00 | H | Las Palmas | W | 4-0 | (1-0) | 22,000 |
| D Tristan 31, 47, 58; R Makaay 79 |
| 9 | 04-Nov-00 | A | Villarreal | L | 2-3 | (1-1) | 15,000 |
| Djalminha 10; W Pandiani 68 |
| 10 | 11-Nov-00 | H | Real Zaragoza | W | 2-0 | (1-0) | 27,000 |
| D Tristan 42, 58 |
| 11 | 18-Nov-00 | A | Osasuna | D | 1-1 | (1-1) | 15,800 |
| L Scaloni 1 |
| 12 | 26-Nov-00 | H | Celta Vigo | W | 1-0 | (0-0) | 36,000 |
| Djalminha 77 |
| 13 | 02-Dec-00 | A | Espanyol | W | 2-0 | (0-0) | 20,000 |
| Fernando 48; R Makaay 55 |
| 14 | 09-Dec-00 | H | Rayo Vallecano | D | 1-1 | (1-0) | 30,000 |
| R Makaay 35 |
| 15 | 16-Dec-00 | A | Alavés | L | 1-3 | (1-2) | 17,000 |
| Victor 17 |
| 16 | 20-Dec-00 | H | Oviedo | W | 3-0 | (1-0) | 22,000 |
| Djalminha 10, 80; R Makaay 51 |
| 17 | 07-Jan-01 | A | Real Valladolid | L | 1-3 | (0-0) | 17,000 |
| W Pandiani 82 |
| 18 | 13-Jan-01 | H | Valencia | W | 2-0 | (0-0) | 36,000 |
| W Pandiani 89; R Makaay 90 |
| 19 | 21-Jan-01 | A | Malaga | W | 3-1 | (1-1) | 25,000 |
| R Makaay 32; L Scaloni 84, 90 |
| 20 | 27-Jan-01 | A | Athletic Bilbao | D | 2-2 | (2-1) | 35,000 |
| R Makaay 36, 39 |
| 21 | 04-Feb-01 | H | Racing Santander | W | 2-1 | (2-1) | 30,000 |
| R Makaay 4, 33 |
| 22 | 11-Feb-01 | H | Real Sociedad | W | 4-1 | (3-0) | 30,000 |
| D Tristan 5, 43, 62; Donato 28 |
| 23 | 17-Feb-01 | A | Barcelona | W | 3-2 | (1-2) | 90,000 |
| Djalminha 7; Victor 72, 90 |
| 24 | 24-Feb-01 | H | Real Madrid | D | 2-2 | (0-2) | 35,000 |
| Djalminha 51p; D Tristan 84 |
| 25 | 03-Mar-01 | A | Real Mallorca | L | 1-2 | (0-1) | 26,000 |
| R Makaay 79 |
| 26 | 10-Mar-01 | H | Numancia | W | 4-1 | (0-0) | 25,000 |
| W Pandiani 50, 60; D Tristan 58, 90 |
| 27 | 17-Mar-01 | A | Las Palmas | L | 0-2 | (0-2) | 17,000 |
| |
| 28 | 31-Mar-01 | H | Villarreal | W | 4-2 | (2-0) | 30,000 |
| Djalminha 20; D Tristan 42, 85; R Makaay 89 |
| 29 | 08-Apr-01 | A | Real Zaragoza | L | 1-2 | (0-1) | 23,000 |
| N Naybet 86 |
| 30 | 14-Apr-01 | H | Osasuna | W | 2-1 | (0-1) | 20,000 |
| R Makaay 51; Fernando 87 |
| 31 | 21-Apr-01 | A | Celta Vigo | L | 1-2 | (0-0) | --,--- |
| J Valeron 54 |
| 32 | 29-Apr-01 | H | Espanyol | W | 1-0 | (1-0) | 22,000 |
| Fran 20 |
| 33 | 06-May-01 | A | Rayo Vallecano | D | 1-1 | (0-0) | 10,000 |
| J Valeron 72 |
| 34 | 11-May-01 | H | Alavés | W | 2-1 | (1-1) | 27,000 |
| D Tristan 45p, 54p |
| 35 | 20-May-01 | A | Oviedo | W | 3-2 | (2-0) | 27,000 |
| D Tristan 17, 22, 65 |
| 36 | 27-May-01 | H | Real Valladolid | L | 1-2 | (0-1) | 30,000 |
| R Makaay 76 |
| 37 | 10-Jun-01 | A | Valencia | W | 1-0 | (0-0) | 45,000 |
| R Makaay 69 |
| 38 | 17-Jun-01 | H | Malaga | W | 4-0 | (1-0) | 32,000 |
| Djalminha 8, 48; R Makaay 58; Victor 79 |
| Spanish Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 13-Dec-00 | A | Universidad Las Palmas | W | 1-0 | (0-0) | 5,000 |
| D Tristan 77 |
| 2 | 03-Jan-01 | A | Tenerife | L | 2-3 | (1-0) | 16,000 |
| L Scaloni 28; W Pandiani 90 |
| UEFA Champions League |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 Gp E | 13-Sep-00 | A | Panathinaikos | D | 1-1 | (0-1) | 55,000 |
| N Naybet 84 |
| 1 Gp E | 19-Sep-00 | H | Hamburg | W | 2-1 | (1-0) | 15,000 |
| W Pandiani 44; L Scaloni 90 |
| 1 Gp E | 26-Sep-00 | A | Juventus | D | 0-0 | (0-0) | 25,000 |
| |
| 1 Gp E | 18-Oct-00 | H | Juventus | D | 1-1 | (1-1) | 25,000 |
| Victor 12 |
| 1 Gp E | 24-Oct-00 | H | Panathinaikos | W | 1-0 | (0-0) | 20,000 |
| W Pandiani 82 |
| 1 Gp E | 08-Nov-00 | A | Hamburg | D | 1-1 | (0-1) | 48,500 |
| R Makaay 58 |
| 2 Gp B | 21-Nov-00 | A | Paris St-Germain | W | 3-1 | (0-1) | 31,800 |
| N Naybet 64; Turu Flores 69; R Makaay 90 |
| 2 Gp B | 06-Dec-00 | H | AC Milan | L | 0-1 | (0-1) | 35,000 |
| |
| 2 Gp B | 14-Feb-01 | A | Galatasaray | L | 0-1 | (0-1) | 19,000 |
| |
| 2 Gp B | 20-Feb-01 | H | Galatasaray | W | 2-0 | (1-0) | 30,000 |
| Victor 39; Djalminha 72p |
| 2 Gp B | 07-Mar-01 | H | Paris St-Germain | W | 4-3 | (0-2) | 28,000 |
| W Pandiani 56, 75, 83; D Tristan 59 |
| 2 Gp B | 13-Mar-01 | A | AC Milan | D | 1-1 | (0-0) | 70,000 |
| Djalminha 74p |
| QF L1 | 04-Apr-01 | A | Leeds United | L | 0-3 | (0-1) | 35,508 |
| |
| QF L2 | 17-Apr-01 | H | Leeds United | W | 2-0 | (1-0) | 35,000 |
| Djalminha 8p; D Tristan 73 |
Home and away results against each team, listed in the current league table standings
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.