| English Premiership |
| No. | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 20-Aug-00 | H | Newcastle United | W | 2-0 | (1-0) | 67,477 |
| Johnsen 21; Cole 70 |
| 2 | 22-Aug-00 | A | Ipswich Town | D | 1-1 | (1-1) | 22,007 |
| Beckham 39 |
| 3 | 26-Aug-00 | A | West Ham United | D | 2-2 | (1-0) | 25,998 |
| Beckham 6; Cole 49 |
| 4 | 05-Sep-00 | H | Bradford City | W | 6-0 | (2-0) | 66,447 |
| Cole 11; Fortune 23, 60; Sheringham 71, 81; Beckham 85 |
| 5 | 09-Sep-00 | H | Sunderland | W | 3-0 | (1-0) | 67,503 |
| Scholes 14, 82; Sheringham 76 |
| 6 | 16-Sep-00 | A | Everton | W | 3-1 | (3-0) | 38,541 |
| Butt 27; Giggs 29; Solskjaer 38 |
| 7 | 23-Sep-00 | H | Chelsea | D | 3-3 | (3-2) | 67,568 |
| Scholes 14; Sheringham 37; Beckham 39 |
| 8 | 01-Oct-00 | A | Arsenal | L | 0-1 | (0-1) | 38,146 |
| |
| 9 | 14-Oct-00 | A | Leicester City | W | 3-0 | (1-0) | 22,132 |
| Sheringham 37, 55; Solskjaer 90 |
| 10 | 21-Oct-00 | H | Leeds United | W | 3-0 | (1-0) | 67,525 |
| Yorke 41; Beckham 50; Jones(og) 83 |
| 11 | 28-Oct-00 | H | Southampton | W | 5-0 | (2-0) | 67,581 |
| Cole 9, 73; Sheringham 45, 51, 55 |
| 12 | 04-Nov-00 | A | Coventry City | W | 2-1 | (2-0) | 21,079 |
| Cole 27; Beckham 37 |
| 13 | 11-Nov-00 | H | Middlesbrough | W | 2-1 | (0-1) | 67,576 |
| Butt 62; Sheringham 65 |
| 14 | 18-Nov-00 | A | Manchester City | W | 1-0 | (1-0) | 34,429 |
| Beckham 2 |
| 15 | 25-Nov-00 | A | Derby County | W | 3-0 | (0-0) | 32,910 |
| Sheringham 61; Butt 69; Yorke 76 |
| 16 | 02-Dec-00 | H | Tottenham Hotspur | W | 2-0 | (1-0) | 67,583 |
| Scholes 40; Solskjaer 84 |
| 17 | 09-Dec-00 | A | Charlton Athletic | D | 3-3 | (2-1) | 20,043 |
| Giggs 42; Solskjaer 43; Keane 66 |
| 18 | 17-Dec-00 | H | Liverpool | L | 0-1 | (0-1) | 67,533 |
| |
| 19 | 23-Dec-00 | H | Ipswich Town | W | 2-0 | (2-0) | 67,597 |
| Solskjaer 20, 32 |
| 20 | 26-Dec-00 | A | Aston Villa | W | 1-0 | (0-0) | 40,889 |
| Solskjaer 85 |
| 21 | 30-Dec-00 | A | Newcastle United | D | 1-1 | (1-0) | 52,134 |
| Beckham 25p |
| 22 | 01-Jan-01 | H | West Ham United | W | 3-1 | (2-0) | 67,603 |
| Solskjaer 3; Stuart Pearce(og) 33; Yorke 58 |
| 23 | 13-Jan-01 | A | Bradford City | W | 3-0 | (0-0) | 20,551 |
| Sheringham 72; Giggs 75; Chadwick 87 |
| 24 | 20-Jan-01 | H | Aston Villa | W | 2-0 | (0-0) | 67,533 |
| Gary Neville 57; Sheringham 87 |
| 25 | 31-Jan-01 | A | Sunderland | W | 1-0 | (0-0) | 48,260 |
| Cole 46 |
| 26 | 03-Feb-01 | H | Everton | W | 1-0 | (0-0) | 67,528 |
| Steve Watson(og) 52 |
| 27 | 10-Feb-01 | A | Chelsea | D | 1-1 | (0-1) | 34,960 |
| Cole 69 |
| 28 | 25-Feb-01 | H | Arsenal | W | 6-1 | (5-1) | 67,535 |
| Yorke 3, 18, 22; Keane 26; Solskjaer 38; Sheringham 90 |
| 29 | 03-Mar-01 | A | Leeds United | D | 1-1 | (0-0) | 40,055 |
| Chadwick 64 |
| 30 | 17-Mar-01 | H | Leicester City | W | 2-0 | (0-0) | 67,516 |
| Solskjaer 88; Silvestre 90 |
| 31 | 31-Mar-01 | A | Liverpool | L | 0-2 | (0-2) | 44,806 |
| |
| 32 | 10-Apr-01 | H | Charlton Athletic | W | 2-1 | (1-0) | 67,505 |
| Cole 45; Solskjaer 82 |
| 33 | 14-Apr-01 | H | Coventry City | W | 4-2 | (2-2) | 67,637 |
| Yorke 12, 27; Giggs 81; Scholes 87 |
| 34 | 21-Apr-01 | H | Manchester City | D | 1-1 | (0-0) | 67,535 |
| Sheringham 71p |
| 35 | 28-Apr-01 | A | Middlesbrough | W | 2-0 | (1-0) | 34,417 |
| Phil Neville 4; Beckham 84 |
| 36 | 05-May-01 | H | Derby County | L | 0-1 | (0-1) | 67,526 |
| |
| 37 | 13-May-01 | A | Southampton | L | 1-2 | (0-2) | 15,246 |
| Giggs 71 |
| 38 | 19-May-01 | A | Tottenham Hotspur | L | 1-3 | (1-1) | 36,072 |
| Scholes 22 |
| English FA Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 3 | 07-Jan-01 | A | Fulham | W | 2-1 | (1-1) | 19,178 |
| Solskjaer 8; Sheringham 89 |
| 4 | 28-Jan-01 | H | West Ham United | L | 0-1 | (0-0) | 67,029 |
| |
| English League Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 3 | 31-Oct-00 | A | Watford | W | 3-0 | (1-0) | 18,871 |
| Solskjaer 12, 81; Yorke 53 |
| 4 | 28-Nov-00 | A | Sunderland | L | 1-2 | (1-0) | 47,543 |
| Yorke 31 [aet] |
| UEFA Champions League |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 Gp G | 13-Sep-00 | H | Anderlecht | W | 5-1 | (3-0) | 62,749 |
| Cole 15, 49, 71; Irwin 30p; Sheringham 41 |
| 1 Gp G | 19-Sep-00 | A | Dynamo Kiev | D | 0-0 | (0-0) | 48,432 |
| |
| 1 Gp G | 26-Sep-00 | A | PSV Eindhoven | L | 1-3 | (1-2) | 28,000 |
| Scholes 2p |
| 1 Gp G | 18-Oct-00 | H | PSV Eindhoven | W | 3-1 | (1-0) | 66,313 |
| Sheringham 9; Scholes 82; Yorke 87 |
| 1 Gp G | 24-Oct-00 | A | Anderlecht | L | 1-2 | (1-2) | 27,500 |
| Irwin 36p |
| 1 Gp G | 08-Nov-00 | H | Dynamo Kiev | W | 1-0 | (1-0) | 66,776 |
| Sheringham 18 |
| 2 Gp A | 21-Nov-00 | H | Panathinaikos | W | 3-1 | (0-0) | 65,024 |
| Sheringham 48; Scholes 81, 90 |
| 2 Gp A | 06-Dec-00 | A | Sturm Graz | W | 2-0 | (1-0) | 16,500 |
| Scholes 17; Giggs 89 |
| 2 Gp A | 14-Feb-01 | A | Valencia | D | 0-0 | (0-0) | 49,451 |
| |
| 2 Gp A | 20-Feb-01 | H | Valencia | D | 1-1 | (1-0) | 66,715 |
| Cole 12 |
| 2 Gp A | 07-Mar-01 | A | Panathinaikos | D | 1-1 | (0-1) | 27,231 |
| Scholes 90 |
| 2 Gp A | 13-Mar-01 | H | Sturm Graz | W | 3-0 | (2-0) | 66,404 |
| Butt 5; Sheringham 20; Keane 87 |
| QF L1 | 03-Apr-01 | H | Bayern Munich | L | 0-1 | (0-0) | 66,584 |
| |
| QF L2 | 18-Apr-01 | A | Bayern Munich | L | 1-2 | (0-2) | 60,000 |
| Giggs 49 |
| Charity Shield |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 14-Aug-00 | N | Chelsea | L | 0-2 | (0-1) | 65,148 |
| |
Home and away results against each team, listed in the current league table standings
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.