| English Div 1 |
| No. | Date | Ven | Opponent | Result | HT | Attend |
| 1 | 12-Aug-00 | A | Queens Park Rangers | D | 0-0 | (0-0) | 13,926 |
| |
| 2 | 18-Aug-00 | H | Fulham | L | 1-3 | (1-3) | 21,659 |
| Sonner 38 |
| 3 | 26-Aug-00 | A | Nottingham Forest | W | 2-1 | (2-0) | 18,820 |
| Marcelo 16; Eaden 45 |
| 4 | 28-Aug-00 | H | Barnsley | W | 4-1 | (2-0) | 17,160 |
| Ndlovu 9; Grainger 35p; Holdsworth 51; Hughes 90 |
| 5 | 09-Sep-00 | H | Sheffield United | W | 1-0 | (1-0) | 21,493 |
| O'Connor 9p |
| 6 | 12-Sep-00 | H | Preston North End | W | 3-1 | (0-1) | 16,464 |
| Ndlovu 58; Andrew Johnson 65; O'Connor 78p |
| 7 | 17-Sep-00 | A | West Bromwich Albion | D | 1-1 | (0-1) | 19,858 |
| Horsfield 61 |
| 8 | 23-Sep-00 | H | Tranmere Rovers | W | 2-0 | (0-0) | 17,640 |
| Grainger 73; Horsfield 90 |
| 9 | 01-Oct-00 | A | Watford | L | 0-2 | (0-0) | 12,355 |
| |
| 10 | 08-Oct-00 | A | Crewe Alexandra | W | 2-0 | (0-0) | 6,829 |
| Hughes 54; Cipriano 81 |
| 11 | 14-Oct-00 | H | Crystal Palace | W | 2-1 | (0-0) | 17,191 |
| Burchill 72; Adebola 85 |
| 12 | 17-Oct-00 | H | Stockport County | W | 4-0 | (1-0) | 15,579 |
| Horsfield 13; Grainger 70p; Burchill 80, 87 |
| 13 | 22-Oct-00 | A | Sheffield Wednesday | L | 0-1 | (0-0) | 14,695 |
| |
| 14 | 25-Oct-00 | H | Gillingham | W | 1-0 | (0-0) | 26,044 |
| Marcelo 90 |
| 15 | 28-Oct-00 | A | Portsmouth | D | 1-1 | (0-1) | 15,218 |
| Adebola 48 |
| 16 | 04-Nov-00 | H | Bolton Wanderers | D | 1-1 | (0-0) | 20,043 |
| Grainger 50p |
| 17 | 07-Nov-00 | A | Norwich City | L | 0-1 | (0-1) | 13,900 |
| |
| 18 | 18-Nov-00 | H | Burnley | W | 3-2 | (0-0) | 19,641 |
| Adebola 48; O'Connor 50; Burchill 86 |
| 19 | 25-Nov-00 | H | Huddersfield Town | W | 2-1 | (2-0) | 22,120 |
| Lazaridis 26; Horsfield 45 |
| 20 | 02-Dec-00 | A | Gillingham | W | 2-1 | (0-1) | 9,247 |
| Michael Johnson 78; Horsfield 90 |
| 21 | 09-Dec-00 | H | Wimbledon | L | 0-3 | (0-2) | 16,778 |
| |
| 22 | 17-Dec-00 | A | Wolverhampton Wndrs | W | 1-0 | (1-0) | 19,938 |
| Adebola 32 |
| 23 | 23-Dec-00 | H | Queens Park Rangers | D | 0-0 | (0-0) | 24,311 |
| |
| 24 | 26-Dec-00 | A | Blackburn Rovers | L | 1-2 | (0-0) | 24,899 |
| Purse 88 |
| 25 | 01-Jan-01 | H | Nottingham Forest | L | 0-2 | (0-0) | 20,034 |
| |
| 26 | 13-Jan-01 | A | Barnsley | W | 3-2 | (2-0) | 13,631 |
| Marcelo 16; Michael Johnson 40; Lazaridis 48 |
| 27 | 27-Jan-01 | A | Fulham | W | 1-0 | (0-0) | 17,077 |
| Grainger 49 |
| 28 | 03-Feb-01 | H | Norwich City | W | 2-1 | (1-0) | 18,551 |
| Hughes 9; Purse 62p |
| 29 | 10-Feb-01 | A | Sheffield United | L | 1-3 | (0-2) | 19,313 |
| Horsfield 89 |
| 30 | 17-Feb-01 | H | West Bromwich Albion | W | 2-1 | (1-1) | 25,025 |
| Adebola 36; O'Connor 57 |
| 31 | 20-Feb-01 | A | Preston North End | W | 2-0 | (1-0) | 14,864 |
| Grainger 11; Andrew Johnson 71 |
| 32 | 02-Mar-01 | H | Watford | W | 2-0 | (1-0) | 20,724 |
| Eaden 45; Hughes 79 |
| 33 | 06-Mar-01 | A | Crystal Palace | W | 2-1 | (0-0) | 13,987 |
| Upson(og) 48; Adebola 59 |
| 34 | 10-Mar-01 | H | Crewe Alexandra | W | 2-0 | (0-0) | 28,042 |
| Purse 61p; Andrew Johnson 77 |
| 35 | 14-Mar-01 | H | Blackburn Rovers | L | 0-2 | (0-1) | 29,150 |
| |
| 36 | 17-Mar-01 | A | Stockport County | L | 0-2 | (0-1) | 7,176 |
| |
| 37 | 20-Mar-01 | A | Grimsby Town | D | 1-1 | (1-1) | 4,843 |
| Andrew Johnson 16 |
| 38 | 24-Mar-01 | H | Sheffield Wednesday | L | 1-2 | (0-1) | 19,733 |
| Horsfield 60 |
| 39 | 01-Apr-01 | H | Wolverhampton Wndrs | L | 0-1 | (0-1) | 24,003 |
| |
| 40 | 07-Apr-01 | A | Wimbledon | L | 1-3 | (0-1) | 6,619 |
| Marcelo 86 |
| 41 | 10-Apr-01 | A | Tranmere Rovers | L | 0-1 | (0-0) | 8,004 |
| |
| 42 | 13-Apr-01 | A | Bolton Wanderers | D | 2-2 | (1-0) | 15,025 |
| O'Connor 14; Marcelo 57 |
| 43 | 16-Apr-01 | H | Portsmouth | D | 0-0 | (0-0) | 23,304 |
| |
| 44 | 21-Apr-01 | A | Burnley | D | 0-0 | (0-0) | 17,057 |
| |
| 45 | 28-Apr-01 | H | Grimsby Town | W | 1-0 | (0-0) | 24,822 |
| Marcelo 64 |
| 46 | 06-May-01 | A | Huddersfield Town | W | 2-1 | (2-1) | 19,290 |
| Woodhouse 21, 45 |
| English FA Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 3 | 06-Jan-01 | A | Manchester City | L | 2-3 | (0-3) | 19,380 |
| Grainger 57; Adebola 61 |
| English League Cup |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| 1 L1 | 22-Aug-00 | A | Southend United | W | 5-0 | (3-0) | 3,694 |
| Eaden 5; Marcelo 10; Michael Johnson 28; Adebola 74; Hughes 85 |
| 1 L2 | 05-Sep-00 | H | Southend United | D | 0-0 | (0-0) | 9,507 |
| |
| 2 L1 | 19-Sep-00 | A | Wycombe Wanderers | W | 4-3 | (3-1) | 2,537 |
| Horsfield 3, 22; Andrew Johnson 24, 87 |
| 2 L2 | 26-Sep-00 | H | Wycombe Wanderers | W | 1-0 | (0-0) | 8,960 |
| Ndlovu 66 |
| 3 | 31-Oct-00 | A | Tottenham Hotspur | W | 3-1 | (3-0) | 27,096 |
| Adebola 15, 28; Burchill 45 |
| 4 | 29-Nov-00 | H | Newcastle United | W | 2-1 | (1-1) | 18,520 |
| Adebola 31; Michael Johnson 90 |
| QF | 12-Dec-00 | H | Sheffield Wednesday | W | 2-0 | (1-0) | 22,911 |
| Sonner 28; Adebola 57 |
| SF L1 | 09-Jan-01 | A | Ipswich Town | L | 0-1 | (0-1) | 21,684 |
| |
| SF L2 | 31-Jan-01 | H | Ipswich Town | W | 4-1 | (1-0) | 28,624 |
| Grainger 43; Horsfield 56, 103; Andrew Johnson 117 [aet] |
| F | 25-Feb-01 | N | Liverpool | D | 1-1 | (0-1) | 73,500 |
| Purse 90p [aet, pen 4-5] |
| Division One Play-offs |
| Round | Date | Ven | Opponent | Result | HT | Attend |
| SF L1 | 13-May-01 | H | Preston North End | W | 1-0 | (0-0) | 29,072 |
| Eaden 55 |
| SF L2 | 17-May-01 | A | Preston North End | L | 1-2 | (0-1) | 16,928 |
| Horsfield 58 [aet, pen 4-2] |
Home and away results against each team, listed in the current league table standings
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.